The 1st thing I suggest checking whenever I hear "uneven fuel usage" is whether there are 2 tanks and the crossover valve has been left open. Fuel is drawn most from the path of least flow resistance and there is always some difference. IMO , it's always best to run one tank to one engine, 2nd tank to 2nd engine, with any crossover closed except in emergency use.
As suggested by others above , there are lots of other causes of uneven usage including engine component condition and related tune ups, generator on one of the tanks, prop effective pitch difference , P/S trim , tank vent (or other ) slight restriction , Suction air leaks in fuel line, sometimes opposite rotation engine and transmission has been reported to make a difference -though it doesn't at all on my boat, whether or not you employ active RPM sync(for much better average sync) and it and your tachs are accurate , difference in fuel quality including octane rating, etc..