The handling of a twin inboard is much more intuitive and simple. Mostly this is due to a) much wider separation of the props, and b) a nice big rudder.
I/Os are usually crammed as closely together as possible, and the skeg hardly qualifies as a rudder. To some extent, this is compensated by the use of "directed thrust".
There are other technical details that usually mean that reverse thrust in an inboard is generally more efficient than reverse from an I/O.
Net result: The handling is quite different. I personally find that inboards are MUCH easier than I/Os, and because of the requirement of using engine thrust to effect a direction change ( vs simple rudder action ), there is much more thrashing about with the engines when maneuvering an I/O.
That said, I would rate twin inboards only slightly more maneuverable than twin i/Os. YMMV.
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Note: I have no experience w/ IPS and they likely handle differently than both of those mentioned above...