yes, if your primary filters are below the top of the fuel tanks, change the filters with a full tank(s). just shut off the valve at the tank connection before changing and use gravity to fill the racors.
you can also install either an electric fuel pump from racor on the bottom of the racor that will prime them, or install a by pass and bulb primer. pics of the later are available at boatdiesel dot com. search tony Athens fuel filter and primer for details.