When an I/O acts jammed up, it's common to remove the Outdrive to show which major component (engine or outdrive) is the source of the binding. Likewise, suggest you drop the Lower Unit, as if you were to replace the water pump.
There is NOT as much friction in an O/B, even a V6, as there is in an automotive engine converted to marine, like an I/O.
A socket that fits the flywheel nut, with just a ratchet, should rotate the powerhead easily, given the sparkplugs are out.
The V4 and V6 OMC O/B's I've tinkered with had a large flywheel nut, probably around 1-1/4". It ought to be safe to rotate the crankshaft with it. If it jams up and won't turn, something's jammed inside.
You might be able to inspect inside the cylinders with a small flashlight.
The head fits through a sparkplug hole and you could get a couple peeks inside each cylinder. Otherwise, powerhead jammed up with plugs out and gearcase removed - see if your model has intake port covers. If so, pull them and look at what you can see of the pistons. Those gaskets are cheaper than Head Gaskets. Pulling Heads would be next.
Some OMC V6 "Looper" engines had a hot spot in a cylinder at the end of the line in the cooling water path. That cylinder, one of the two lower ones and I forget which, would blow. You might pull an Intake Cover and God Forbid see damage or find bearing needles. That would be Very Bad, but would be an answer.