One of our flotilla members had a '99 260DA with a 350/5.7 and B-3. Had a/c but no genset. Ran out well with 4POB, we could cruise on plane in the low-mid 3000s. It had the original trim tabs, was stored hi-dri, no bottom paint.
I'm asking him for information, but from my onboard experience with his, something's hokey with yours. What was the "cleaning" you mentioned earlier? You said it in connetion with "prop shop" but I think everybody here is looking at this assuming you have a clean unpainted bottom. If it's fouled, the boat will be a dog.
Given it's clean and you verified 4950 with MerC test equipment and the right props, I'd say the drive angle is wrong, boat hull is distored, or it's overloaded, maybe full of water someplace you haven't found.